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Resumo Objetivo Existem poucos estudos multinacionais sobre os resultados do tratamento da neoplasia trofoblástica gestacional (NTG) na América do Sul. O objetivo deste estudo foi avaliar a apresentação clínica, os resultados do tratamento e os fatores associados a casos de quimiorresistência em NTG pós-molar de baixo risco tratados com quimioterapia de agente único de primeira linha em três centros sul-americanos. Métodos Estudo multicêntrico de coorte histórica incluindo mulheres com NTG pós-molar de baixo risco com estadiamento International Federation of Gynecology and Obstetrics (FIGO) em centros de atendimento na Argentina, Brasil e Colômbia entre 1990 e 2014. Foram obtidos dados sobre as características do paciente, apresentação da doença e resposta ao tratamento. A regressão logística foi usada para avaliar a relação entre fatores clínicos e resistência ao tratamento de primeira linha com agente único. Foi realizada uma análise multivariada dos fatores clínicos significativos na análise univariada. Resultados Cento e sessenta e três mulheres com NTG de baixo risco foram incluídas na análise. A taxa global de resposta completa à quimioterapia de primeira linha foi de 80% (130/163). As taxas de resposta completa ao metotrexato ou actinomicina-D como tratamento de primeira linha e actinomicina-D como tratamento de segunda linha após falha do metotrexato foram 79% (125/157), 83% (⅚) e 70% (23/33), respectivamente. A mudança para o tratamento de segunda linha por quimiorresistência ocorreu em 20,2% dos casos (33/163). A análise multivariada demonstrou que pacientes com pontuação de risco FIGO de 5 a 6 foram 4,2 vezes mais propensos a desenvolver resistência ao tratamento com agente único de primeira linha (p= 0,019). Conclusão 1) Na apresentação, a maioria das mulheres demonstrou características clínicas favoráveis a um bom resultado, 2) a taxa geral de remissão completa sustentada após o tratamento de primeira linha com agente único foi comparável à de países desenvolvidos, 3) um escore de risco FIGO de 5 ou 6 está associado ao desenvolvimento de resistência à quimioterapia de agente único de primeira linha.

Abstract Objective There are few multinational studies on gestational trophoblastic neoplasia (GTN) treatment outcomes in South America. The purpose of this study was to assess the clinical presentation, treatment outcomes, and factors associated with chemoresistance in low-risk postmolar GTN treated with first-line single-agent chemotherapy in three South American centers. Methods Multicentric, historical cohort study including women with International Federation of Gynecology and Obstetrics (FIGO)-staged low-risk postmolar GTN attending centers in Argentina, Brazil, and Colombia between 1990 and 2014. Data were obtained on patient characteristics, disease presentation, and treatment response. Logistic regression was used to assess the relationship between clinical factors and resistance to first-line single-agent treatment. A multivariate analysis of the clinical factors significant in univariate analysis was performed. Results A total of 163 women with low-risk GTN were included in the analysis. The overall rate of complete response to first-line chemotherapy was 80% (130/163). The rates of complete response to methotrexate or actinomycin-D as first-line treatment, and actinomycin-D as second-line treatment postmethotrexate failure were 79% (125/157), 83% (⅚), and 70% (23/33), respectively. Switching to second-line treatment due to chemoresistance occurred in 20.2% of cases (33/163). The multivariate analysis demonstrated that patients with a 5 to 6 FIGO risk score were 4.2-fold more likely to develop resistance to first-line single-agent treatment (p= 0.019). Conclusion 1) At presentation, most women showed clinical characteristics favorable to a good outcome, 2) the overall rate of sustained complete remission after first-line single-agent treatment was comparable to that observed in developed countries, 3) a FIGO risk score of 5 or 6 is associated with development of resistance to first-line single-agent chemotherapy.

https://doi.org/10.1055/s-0042-1748974

Aplicación de una ley matemática exponencial a la dinámica cardíaca en 16 horas: estudio realizado con 250 pacientes
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Prieto-Bohórquez, Signed E.

; Rodríguez-Velásquez, Javier

; Correa-Herrera, Catalina

; Beltrán, Luis M.

; Agudelo-Otalora, Luis M.

; Trejos-Ramírez, Carlos

; Pérez-Molina, Clímaco

Revista Colombiana de Cardiología

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Jun 2021, Volume 28 Nº 3 Páginas 231 - 238

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Introducción: Los sistemas dinámicos y la geometría fractal han sido el sustrato para el advenimiento de una ley matemática aplicada al diagnóstico de la dinámica cardíaca en 21 horas. Objetivo: Confirmar la aplicabilidad clínica de la ley matemática exponencial en 16 horas a partir de un estudio de concordancia diagnóstica frente a la norma de referencia. Materiales y método: Se realizó un estudio con 250 registros electrocardiográficos continuos y ambulatorios; 50 pertenecían a pacientes normales y 200 a pacientes con diversas enfermedades cardíacas. Se simuló la secuencia de frecuencias cardíacas y se construyeron los atractores correspondientes. Se calculó la dimensión fractal y la ocupación del atractor en el espacio generalizado de box-counting. Por último, se estableció el diagnóstico fisicomatemático en 16 y 21 horas y se efectuó la validación estadística. Resultados: Los espacios de ocupación para normalidad en la rejilla pequeña se encontraron entre 205 y 372, y entre 56 y 201 para dinámicas patológicas, lo cual permitió evidenciar la capacidad del método para diferenciar normalidad de enfermedad a través de la ocupación espacial de los atractores con base en la ley matemática en 16 horas. Se hallaron valores de sensibilidad y especificidad del 100% y un coeficiente kappa del orden de 1, luego de comparar el diagnóstico fisicomatemático frente a la norma de referencia. Conclusión: La ley matemática exponencial en 16 horas demostró su utilidad como herramienta de ayuda diagnóstica y predictiva, lo cual permitió diferenciar normalidad y estados evolutivos hacia enfermedad y agudización.

Abstract Introduction: Dynamic systems and fractal geometry have been the substrate for the rising of a mathematical law applied to the diagnosis of cardiac dynamics in 21 hours. Objective: To confirm the clinical applicability of the exponential mathematical law in 16 hours, with a study of diagnostic agreement against the Gold Standard. Materials and method: It was made a study with 250 ambulatory and continuous electrocardiographic recordings, 50 belonged to normal patients and 200 to patients with various cardiac pathologies. The sequence of heart rates was simulated, and attractors were constructed. It was calculated the fractal dimension of the attractor and its occupation in the generalized Box-Counting space. Finally, it was determined the physical-mathematical diagnostic in 16 and 21 hours, and statistical validation was performed. Results: The occupation spaces in the small grid were between 205 and 372 for normality, and between 56 and 201 for pathologic dynamics, which demonstrated the ability of the method to differentiate normal condition from sickness, through spatial occupation of attractors according to mathematical law in 16 hours. There were obtained values of sensitivity and specificity of 100% and Kappa coefficient was 1, after comparing the physic-mathematical analysis against the Gold Standard. Conclusion: The exponential mathematical law in 16 hours proved its utility as diagnostic and predictive tool support, allowing to differentiate normal, developmental stages to disease and exacerbation.

https://doi.org/10.24875/rccar.m21000024 42 downloads

Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital
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Fink, Thais T.

; Marques, Heloisa H.S.

; Gualano, Bruno

; Lindoso, Livia

; Bain, Vera

; Astley, Camilla

; Martins, Fernanda

; Matheus, Denise

; Matsuo, Olivia M.

; Suguita, Priscila

; Trindade, Vitor

; Paula, Camila S.Y.

; Farhat, Sylvia C.L.

; Palmeira, Patricia

; Leal, Gabriela N.

; Suzuki, Lisa

; Odone Filho, Vicente

; Carneiro-Sampaio, Magda

; Duarte, Alberto José S.

; Antonangelo, Leila

; Batisttella, Linamara R.

; Polanczyk, Guilherme V.

; Pereira, Rosa Maria R.

; Carvalho, Carlos Roberto R.

; Buchpiguel, Carlos A.

; Latronico, Ana Claudia

; Seelaender, Marilia

; Silva, Clovis Artur

; Pereira, Maria Fernanda B.

; Sallum, Adriana M. E.

; Brentani, Alexandra V. M.

; Neto, Álvaro José S.

; Ihara, Amanda

; Santos, Andrea R.

; Canton, Ana Pinheiro M.

; Watanabe, Andreia

; Santos, Angélica C. dos

; Pastorino, Antonio C.

; Franco, Bernadette D. G. M.

; Caruzo, Bruna

; Ceneviva, Carina

; Martins, Carolina C. M. F.

; Prado, Danilo

; Abellan, Deipara M.

; Benatti, Fabiana B.

; Smaria, Fabiana

; Gonçalves, Fernanda T.

; Penteado, Fernando D.

; Castro, Gabriela S. F. de

; Gonçalves, Guilherme S.

; Roschel, Hamilton

; Disi, Ilana R.

; Marques, Isabela G.

; Castro, Inar A.

; Buscatti, Izabel M.

; Faiad, Jaline Z.

; Fiamoncini, Jarlei

; Rodrigues, Joaquim C.

; Carneiro, Jorge D. A.

; Paz, Jose A.

; Ferreira, Juliana C.

; Ferreira, Juliana C. O.

; Silva, Katia R.

; Bastos, Karina L. M.

; Kozu, Katia

; Cristofani, Lilian M.

; Souza, Lucas V. B.

; Campos, Lucia M. A.

; Silva Filho, Luiz Vicente R. F.

; Sapienza, Marcelo T.

; Lima, Marcos S.

; Garanito, Marlene P.

; Santos, Márcia F. A.

; Dorna, Mayra B.

; Aikawa, Nadia E.

; Litvinov, Nadia

; Sakita, Neusa K.

; Gaiolla, Paula V. V.

; Pasqualucci, Paula

; Toma, Ricardo K.

; Correa-Silva, Simone

; Sieczkowska, Sofia M.

; Imamura, Marta

; Forsait, Silvana

; Santos, Vera A.

; Zheng, Yingying

Clinics

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2021, Volume 76 elocation e3511

Resumo: En | Texto: En | PDF: En

OBJECTIVES: To prospectively evaluate demographic, anthropometric and health-related quality of life (HRQoL) in pediatric patients with laboratory-confirmed coronavirus disease 2019 (COVID-19) METHODS: This was a longitudinal observational study of surviving pediatric post-COVID-19 patients (n=53) and pediatric subjects without laboratory-confirmed COVID-19 included as controls (n=52) was performed. RESULTS: The median duration between COVID-19 diagnosis (n=53) and follow-up was 4.4 months (0.8-10.7). Twenty-three of 53 (43%) patients reported at least one persistent symptom at the longitudinal follow-up visit and 12/53 (23%) had long COVID-19, with at least one symptom lasting for >12 weeks. The most frequently reported symptoms at the longitudinal follow-up visit were headache (19%), severe recurrent headache (9%), tiredness (9%), dyspnea (8%), and concentration difficulty (4%). At the longitudinal follow-up visit, the frequencies of anemia (11% versus 0%, p=0.030), lymphopenia (42% versus 18%, p=0.020), C-reactive protein level of >30 mg/L (35% versus 0%, p=0.0001), and D-dimer level of >1000 ng/mL (43% versus 6%, p=0.0004) significantly reduced compared with baseline values. Chest X-ray abnormalities (11% versus 2%, p=0.178) and cardiac alterations on echocardiogram (33% versus 22%, p=0.462) were similar at both visits. Comparison of characteristic data between patients with COVID-19 at the longitudinal follow-up visit and controls showed similar age (p=0.962), proportion of male sex (p=0.907), ethnicity (p=0.566), family minimum monthly wage (p=0.664), body mass index (p=0.601), and pediatric pre-existing chronic conditions (p=1.000). The Pediatric Quality of Live Inventory 4.0 scores, median physical score (69 [0-100] versus 81 [34-100], p=0.012), and school score (60 [15-100] versus 70 [15-95], p=0.028) were significantly lower in pediatric patients with COVID-19 at the longitudinal follow-up visit than in controls. CONCLUSIONS: Pediatric patients with COVID-19 showed a longitudinal impact on HRQoL parameters, particularly in physical/school domains, reinforcing the need for a prospective multidisciplinary approach for these patients. These data highlight the importance of closer monitoring of children and adolescents by the clinical team after COVID-19.

https://doi.org/10.6061/clinics/2021/e3511

How are HCV-infected patients being identified in Brazil: a multicenter study
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Portari-Filho, Luiz H.

; Álvares-da-Silva, Mario R.

; Gonzalez, Aline

; Ferreira, Adalgisa P.

; Nogueira, Cristiane V.

; Mendes-Correa, Maria C.

; Lima, José M.

; Lopes, Edmundo P.

; Brandão, Carlos E.

; Ivantes, Cláudia

; Lyra, André

; Lindenberg, Andreia

; Ferraz, Maria L.

Brazilian Journal of Infectious Diseases

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Jan 2019, Volume 23 Nº 1 Páginas 34 - 39

Resumo: En | Texto: En | PDF: En

ABSTRACT Background: Hepatitis C is an important health problem. In Brazil, 1-2 million people are infected. Despite this expressive number, and the availability of very successful treatment, many patients remained undiagnosed mainly because of the asymptomatic nature of the infection. Objectives: To describe epidemiological characteristics of HCV-infected patients seen at referral centers in Brazil, the source of referral, and the time spanned to reach a reference center, in order to improve the identification of undiagnosed patients. Methods: Multicenter observational, cross-sectional study carried out in 15 centers of Brazil, between January/2016 and June/2017. Data of patients with a confirmed diagnosis (anti-HCV and HCV-RNA) were collected by interview using standard questionnaires and by review of charts. Results: Two thousand patients were included; 55.1% were male, mean age 58 ± 11 years. Only 14.9% had higher education and 84.2% received up to five monthly minimum Brazilian wages (approximately US$260.00/month). The time between diagnosis and beginning of follow-up was 22.9 months. The most common reasons for testing were check-up (33.2%) and blood donation (19%). General practitioners diagnosed most of the patients (30.1%). Fibrosis stage was mainly evaluated by liver biopsy (61.5%) and 31.3% of the patients were cirrhotic at diagnosis. Conclusions: This multicenter Brazilian study showed that the mean time to reach a referral center for treatment was almost two years. Primary care physicians diagnoses most hepatitis C cases in the country. Population campaigns and medical education should be encouraged to intensify screening of asymptomatic individuals, considering the efficiency of check-ups in identifying new patients.

https://doi.org/10.1016/j.bjid.2019.01.006 533 downloads

Valores ecocardiográficos de referencia de las cavidades derechas en una población sana
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SEGOVIA, ARACELI B.

; KILLINGER, GISELA M.

; GARATE, LAURA

; SALINAS, NINA

; MANENTE, DIEGO

; FILIPUZZI, JUAN M.

; CORREA, CARLOS A, RODRÍGUEZ

Revista argentina de cardiología

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Dez 2018, Volume 86 Nº 6 Páginas 33 - 39

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT Background: The evaluation of right-sided heart chambers is extremely important for the diagnosis and prognosis of differ-ent conditions. However, there is little information in the bibliography about the reference values of the right-sided heart chambers dimensions and right ventricular function. Objective: The aim of this study was to establish the reference values of the right-sided heart chambers, to identify the dif-ferences associated with sex and anthropometric variables and to evaluate the interobserver and intraobserver variability in determining these values. Methods: The study included healthy men and women ≥16 years. Strict exclusion criteria were applied. A subgroup of 40 people underwent multiple measurementis of the right-sided heart chambers and interobserver and intraobserver variability was estimated. Resultis: A total of 438 persons were included; 55.2% (n=242) were men. Mean age was 34±9 years. There were significant differences in the variables analyzed between men and women that persisted after they were indexed to body surface area. Interobserver concordance (ICC>0.75) was excellent in 50% of the variables evaluated, fair to good (ICC 0.4 to 0.75) in 47.4% and poor (ICC<0.4) in 2.6%. Intraobserver concordance was excellent in 54.8% of the variables, fair to good in 42.8% and poor in 2.4%. Conclusion: The reference values for the evaluation of right-sided heart chambers are presented. The differences observed between sexes and related to body surface area emphasize the need for discriminating according to these parameters in daily practice. Interobserver and intraobserver concordance was excellent to good in most of the variables analyzed.

RESUMEN Introducción: La evaluación de las cavidades cardíacas derechas es de gran importancia diagnóstica y pronóstica en diversas patologías. Sin embargo, existen pocos datos bibliográficos acerca de los valores de referencia de sus dimensiones así como de la función del ventrículo derecho. Objetivo: Nuestro objetivo fue establecer dichos valores, identificar diferencias asociadas al sexo y a variables antropométricas y evaluar la variabilidad inter- e intraobservador en su determinación. Material y métodos: Se incluyeron prospectivamente personas sanas ≥ 16 años, de ambos sexos. Se aplicaron estrictos criterios de exclusión. Se realizó la evaluación ecocardiográfica con múltiples mediciones de cavidades derechas y la estimación de la variabilidad inter- e intraobservador en un subgrupo de 40 personas. Resultados: Se incluyeron 438 personas, el 55,2% (n = 242) fueron hombres. La media de edad fue 34 ± 9 años. Las variables analizadas mostraron diferencias significativas entre hombres y mujeres, que persistieron al indexarlas a superficie corporal. La fuerza de concordancia para la variabilidad interobservador fue excelente (CCI > 0,75) en el 50% de las variables estudiadas, regular a buena (CCI 0,4 a 0,75) en el 47,4% y pobre (CCI < 0,4) en el 2,6%. La concordancia intraobservador fue excelente en el 54,8% de las variables, regular a buena en el 42,8% de ellas y pobre en el 2,4%. Conclusión: Presentamos valores de referencia para la evaluación de las cavidades derechas. Las diferencias observadas entre sexos y según la superficie corporal hacen necesaria su discriminación acorde con dichos parámetros en la práctica diaria. La concordancia interobservador e intraobservador fue excelente a buena en la mayoría de las variables estudiadas.

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HIV-1 Antiretroviral Resistance in Cuba, 2009–2014
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Alemán-Campos, Yoan

; Kourí-Cardellá, Vivian

; Pérez-Santos, Lissette

; Fonseca-Gómez, Carlos

; Pérez-Avila, Jorge

; Ortega-González, Lilia M.

; Baños-Morales, Yoanna

; Álvarez-López, Alina

; Correa-Sierra, Consuelo

; Martínez-Montesinos, Yenisleidys

; Soto-Brito, Yudira

; Limia-León, Celia M.

; Campos-Díaz, Jorge

; Caturla-Fernández, Yaniris

; Alvarez-Gainza, Delmis

; Pintos-Saavedra, Yanet

; Añé-Kourí, Ana L.

; Joanes-Fiol, José

MEDICC Review

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Set 2018, Volume 20 Nº 3 Páginas 15 - 21

Resumo: En | Texto: En | PDF: En

ABSTRACT INTRODUCTION By the end of 2017, there were more than 28,000 individuals living with HIV in Cuba, over 80% receiving antiretroviral therapy, which dramatically reduces viral replication, improves immune status and decreases risk of transmission. These results could be jeopardized by emergence of HIV-1 drug resistance. In 2009, a test for HIV-1 genotypic resistance was introduced in routine clinical practice in Cuba. OBJECTIVE Investigate antiretroviral resistance and its relation to subtype distribution in HIV-1 treatment-naïve and previously treated patients in Cuba. METHODS Resistance and HIV-1 subtype distribution were determined in 342 antiretroviral treatment-naïve patients and 584 previously treated for HIV-1 whose blood specimens were sent to the Pedro Kourí Tropical Medicine Institute during 2009–2014. Transmitted drug resistance was determined using the Calibrated Population Resistance Tool v.6. Drug resistance analysis was conducted using the algorithm Rega v9.1.0. RESULTS Prevalence of transmitted drug resistance was 11.4%, and 41% of mutated viruses exhibited dual-class resistance to nucleoside reverse transcriptase inhibitor and non-nucleoside reverse transcriptase inhibitor. Overall, 84.9% of patients had ≥1 resistance mutation, 80% had ≥1 nucleoside reverse transcriptase inhibitor mutation, 71.4% had ≥1 non-nucleoside reverse transcriptase inhibitor mutation and 31.7% had ≥1 protease inhibitor mutation. K65R and K101E mutations were significantly more frequent in subtype C, L210W in CRF19_cpx, and M47V/I in CRF BGs (20, 23, 24). Full class resistance to nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, protease inhibitors and multidrug resistance were detected in 21.2%, 32.4%, 8% and 4.1% of patients, respectively. Average percentage resistance to nucleoside reverse transcriptase inhibitor, protease inhibitor, full class resistance to nucleoside reverse transcriptase inhibitor, protease inhibitor and multidrug resistance increased in patients failing two or more regimens. Nevertheless, after 2011, a declining trend was observed in the frequency of multidrug resistance and full class resistance to nucleoside reverse transcriptase inhibitors and protease inhibitors. CONCLUSIONS Detected levels of transmitted drug resistance highlight the need for a national surveillance study in treatment-naïve patients. Resistance prevalence is high in previously treated patients but appears to be decreasing over time. The frequency of resistance mutations in recombinant forms of HIV in Cuba needs further study.

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Predicción espacio-temporal probabilista de la epidemia de dengue total y grave en Colombia
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Rodríguez-Velásquez, Javier O.

; Prieto-Bohórquez, Signed E.

; Pérez-Díaz, Carlos E.

; Pardo-Oviedo, Juan M.

; Correa-Herrera, Sandra C.

; Mendoza-Beltrán, Fernán del Cristo

; Bravo-Ojeda, Juan S.

; Morales-Pertuz, Carlos A.

; Rojas-Avila, Nydia A.

; Flórez-Cárdenas, Milena

Revista de Salud Pública

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Jun 2018, Volume 20 Nº 3 Páginas 352 - 358

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

RESUMEN Objetivo Establecer una nueva metodología predictiva de la proporción de dengue grave respecto al total anual de infectados de dengue por departamento con base en la teoría de la probabilidad. Métodos Con base en los datos anuales de número de infectados por departamentos en el periodo 2005 -2010, se calculó la proporción entre casos de dengue grave respecto al total para cada año, y se construyeron espacios de probabilidad que evalúan estos eventos en rangos de 0,5 y 0,3. Se determinaron conjuntos de rangos y se calculó probabilidad, desviación media cuadrática y la diferencia entre ellas. Se realizó una predicción del rango de infectados para el 2011 con el promedio aritmético de los valores de los últimos dos años. Resultados Se predijo correctamente el rango en el que se encuentra incluida la proporción de número de infectados de dengue grave sobre el total en cada departamento con una efectividad del 93,3% para el rango de 0,5 y de 86,7% para el de 0,3. Conclusión Se evidenció una autoorganización matemática espacio temporal en la proporción de dengue grave respecto al total que permite establecer predicciones de utilidad para la toma de decisiones de salud pública.

ABSTRACT Objective To establish a new predictive methodology to determine the proportion of severe dengue with respect to the annual total of dengue infections per department based on the probability theory. Materials and Methods Based on annual data on the number of infected persons by department in the period 2005-2010, the proportion of cases of severe dengue was calculated with respect to the total for each year. Probability spaces were constructed to evaluate these events in the ranges 0.5 and 0.3. Sets of ranges were determined and probability, mean square deviation and the difference between them were estimated. A prediction of the range of infected people for 2011 was made using the arithmetic average of the values of the last two years. Results The range in which the proportion of the number of people infected with severe dengue is included with respect to the total amount in each department was correctly predicted, with an effectiveness of 93.3% for the 0.5 range and 86.7% for the 0.3 range. Conclusion A mathematical spatial-temporal self-organization was found in the proportion of severe dengue with respect to the total, which allows establishing useful predictions for decision-making in public health.

https://doi.org/10.15446/rsap.v20n3.42701 286 downloads

Predicción espacio-temporal probabilista de la epidemia de dengue total y grave en Colombia
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Rodríguez-Velásquez, Javier O.

; Prieto-Bohórquez, Signed E.

; Pérez-Díaz, Carlos E.

; Pardo-Oviedo, Juan M.

; Correa-Herrera, Sandra C.

; Mendoza-Beltrán, Fernán del Cristo

; Bravo-Ojeda, Juan S.

; Morales-Pertuz, Carlos A.

; Rojas-Avila, Nydia A.

; Flórez-Cárdenas, Milena

Revista de Salud Pública

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Jun 2018, Volume 20 Nº 3 Páginas 352 - 358

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

https://doi.org/10.15446/rsap.v20n3.42701

Validation of honey-bee smelling profile by using a commercial electronic nose
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Correa, Ana R.

; Cuenca, Martha M.

; Zuluaga, Carlos M.

; Scampicchio, Matteo M.

; Quicazán, Marta C.

Ingeniería e Investigación

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Dez 2017, Volume 37 Nº 3 Páginas 45 - 51

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

RESUMEN La miel es utilizada como edulcorante natural. El origen botánico o geográfico de las mieles se establece mediante análisis palinológico y sensorial. El uso de técnicas rápidas como la nariz electrónica puede ser una alternativa para la clasificación de mieles. En este estudio se validaron los parámetros operativos de una nariz electrónica comercial para determinar el perfil del olor de miel. Se utilizó un diseño compuesto central con cinco factores, tres niveles y 28 ensayos, variando la cantidad de muestra (1, 2 y 3 g), la temperatura de incubación (30, 40 y 50 °C), el tiempo de incubación (10, 20 y 30 min), el flujo de gas (50, 150 y 250 mL/min) y el tiempo de inyección (100, 200 y 300 s). La nariz comercial contaba con diez sensores. La repetibilidad se evaluó con un coeficiente de variación de 10 %>. Se utilizó la metodología de superficie de respuesta y se encontraron las siguientes condiciones: 3 g de muestra, incubación a 50 °C por 17 min, flujo de gas de 100 mL/min y tiempo de muestreo de 150 s. Finalmente, estos parámetros se utilizaron para analizar 19 muestras de miel, las cuales se clasificaron según sus perfiles de olor, demostrando así que puede ser una herramienta útil para clasificar mieles.

ABSTRACT Honey is a natural sweetener and its quality labels are associated to its botanical or geographical origin, which is being established by palynological and sensorial analysis. The use of fast and non-invasive techniques such as an electronic nose can become an alternative for honey classification. In this study, the operational parameters of a commercial electronic nose were validated to determine the honey odor profile. A central composite design with five factors, three levels and 28 assays was used, varying sample amounts (1, 2 and 3 g), incubation temperature (30, 40 and 50 °C), incubation time 30 min), gas flow (50, 150 and 250 mL/min) and injection time (100, 200 and 300 s). The commercial nose had ten sensors. Repeatability was evaluated with a coefficient of variation of 10 %. The response surface methodology was used and the optimal operating conditions were: 3 g of sample, incubation at 50 °C for 17 min, gas flow of 100 mL/min and sampling time of 150 s. Finally, these parameters were used to analyze 19 samples of honey, which were classified according to their odor profiles, showing that it can be a useful tool to classify honey.

https://doi.org/10.15446/ing.investig.v37n3.59656 437 downloads

10.

REVISIÓN - EFECTO DEL SISTEMA DE VULCANIZACIÓN EN LA RED ENTRECRUZADA Y EN LA REACCIÓN QUÍMICA DE VULCANIZACIÓN DEL CAUCHO NATURAL
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Urrego-Yepes, William

; Velásquez-Restrepo, Sandra M.

; Giraldo-Vásquez, Diego H.

; Posada Correa, Juan Carlos

Revista EIA

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Dez 2017, Volume 14 Nº 28 Páginas 99 - 115

Resumo: Es En Pt | Texto: Es En Pt | PDF: Es | PDF: En | PDF: Pt

RESUMEN Se presenta una revisión sobre el efecto del sistema de vulcanización en la estructura formada durante la reacción de vulcanización, en la cinética de la reacción y en las propiedades de formulaciones que emplean caucho natural. Se encontró que aún existen aspectos por investigar dada la variedad de acelerantes, proporciones acelerante/azufre, tipos de caucho natural y formulaciones que emplean caucho natural. La mayor parte de la literatura evalúa la reacción de vulcanización mediante reometría de vulcanización y calorimetría diferencial de barrido (DSC), pero estas técnicas no permiten identificar el tipo de enlaces sulfídicos formados ni la densidad de enlaces entrecruzados. La temática es de gran interés científico e industrial pues el caucho natural es el caucho más comercializado a nivel mundial, y su vulcanización se realiza en la gran mayoría de las formulaciones empleando azufre como agente entrecruzante.

ABSTRACT This work presents a review on the effect of the vulcanization system on the crosslinked structure formed during vulcanization reaction and the properties of natural rubber-based materials. These topics have been subject of research because of the wide variety of accelerants, accelerant/sulphur ratios, types of natural rubber and natural rubber-based formulations. Most of the studies use rheometry and differential scanning calorimetry (DSC) for evaluating natural rubber vulcanization, but both techniques do not provide information about the type of sulfidic crosslinks or the crosslinks density. The theme is of great scientific and industrial interest because natural rubber is the most traded rubber worldwide, and its vulcanization is carried out in the vast majority of formulations using sulfur as crosslinking agent.

RESUMO Este trabalho apresenta uma revisão sobre o efeito do sistema de vulcanização na estrutura formada durante a reação de vulcanização, na cinética da reação e nas propriedades das formulações que utilizam borracha natural. Esses tópicos tem sido objeto de pesquisa devido à grande variedade de acelerantes, proporções acelerante/enxofre, tipos de borracha natural e formulações baseadas em borracha natural. A maioria dos estudos utiliza reometria e calorimetria de varredura diferencial (DSC) para avaliar a vulcanização da borracha natural, mas ambas as técnicas não fornecem informação sobre o tipo de ligações sulfídicas ou a densidade de reticulação. O tema é de grande interesse científico e industrial porque a borracha natural é a borracha mais comercializada em todo o mundo, e sua vulcanização é realizada na grande maioria das formulações usando o enxofre como agente de reticulação.

https://doi.org/10.24050/reia.v14i28.1144 981 downloads

11.

Spectral-temporal characterization of wheat cultivars through NDVI obtained by terrestrial sensors
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Cattani, Carlos E. V.

; Garcia, Murilo R.

; Mercante, Erivelto

; Johann, Jerry A.

; Correa, Marcus M.

; Oldoni, Lucas V.

Revista Brasileira de Engenharia Agrícola e Ambiental

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Nov 2017, Volume 21 Nº 11 Páginas 769 - 773

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Aplicações de sensoriamento remoto na agricultura se apresentam como realidade muito promissora, contudo ainda há necessidade de pesquisas para a correta utilização dos dados espectrais. Objetivou-se, neste estudo, avaliar os padrões espectro-temporais de onze cultivares de trigo (Triticum aestivum L.). O experimento foi conduzido, em Cascavel, PR, no ano de 2014. Com o auxílio dos sensores terrestres GreenSeeker e FieldSpec 4 foram determinadas assinaturas espectrais e criados os perfis temporais do Índice de Vegetação por Diferença Normalizada (NDVI). Verificou-se diferenças estatísticas entre as cultivares de trigo por meio da análise de variância (ANOVA) e do teste de médias de Scott-Knott. Correlacionaram-se as produtividades de grãos obtidas com os fatores INSEY (IN-Season Estimate of Yield). O NDVI normalizado por graus-dias acumulados dos estádios de desenvolvimento Feekes 2 e 8, mostrou-se mais consistente na estimativa da produtividade de grãos, explicando aproximadamente 70% da variação. No estádio Feekes 10.1, as cultivares de trigo apresentaram padrões espectrais diferentes nas faixas do infravermelho próximo e médio. Isto sugere que essas bandas espectrais podem ser utilizadas para diferenciar as cultivares de trigo.

ABSTRACT Remote sensing applications in agriculture are presented as a very promising reality, but research is still needed for the correct use of spectral data. The objective of this study was to evaluate the spectral-temporal patterns of eleven wheat cultivars (Triticum aestivum L.). The experiment was conducted in Cascavel, PR, in the year 2014. With the help of the GreenSeeker and FieldSpec 4 terrestrial sensors, spectral signatures were determined and the temporal profiles of the Normalized Difference Vegetation Index (NDVI) were created. Statistical differences between wheat cultivars were analysed using analysis of variance (ANOVA) and Scott-Knott test. Grain yields obtained with INSEY (In-Season Estimate of Yield) factors were correlated. NDVI normalized by degree-days accumulated from the Feekes growth stages 2 and 8 showed to be more consistent in the estimation of grain yield, explaining approximately 70% of the variation. At the Feekes stage 10.1, wheat cultivars presented different spectral patterns in the near and medium infrared bands. This suggests that these spectral bands can be used to differentiate wheat cultivars.

https://doi.org/10.1590/1807-1929/agriambi.v21n11p769-773 1435 downloads

12.

Una propuesta de modelo fisiológico de servicio de urgencias hospitalario. Principios de funcionamiento, tipificación de la saturación y pautas para el rediseño
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Herrera Carranza, M.

; Aguado Correa, F.

; Padilla Garrido, N.

; López Camacho, F.

Anales del Sistema Sanitario de Navarra

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Abr 2017, Volume 40 Nº 1 Páginas 11 - 24

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract The operation of Emergency Departments (ED) is determined by demand, their own organizational structures and the connection to other medical care levels. When these elements are not simultaneous, it hinders patient flow and decreases capacity, making it necessary to employ a systemic approach to the chain of emergency care as a single operational entity. With this theoretical orientation, we suggest a conceptual model similar to the physiological cardiac output, in which the preload is the demand, the contractile or flow pump is the organizational structure, the afterload is the hospital, the pre-ED valve is primary care and outpatient emergencies, and the post-ED valve is the diagnostic support services and the specialist consultants. Based on this theoretical approach we classify the different types of ED overcrowding and systematise its causes and the different waiting lists that it generates, which can help to redesign the service and avoid its saturation.

Resumen El funcionamiento de los servicios de urgencias hospitalarios (SUH) está determinado por la demanda, la estructura organizativa propia y la conexión con los otros niveles asistenciales. La asincronía entre estos elementos dificulta el flujo de pacientes y merma la capacidad, siendo necesario emplear un enfoque sistémico de la cadena asistencial urgente como una entidad funcional única. Con esta orientación presentamos un modelo teórico conceptual, similar al fisiológico del gasto cardíaco, en el que la precarga es la demanda, la bomba contráctil o de flujo la organización interna propia, la poscarga el hospital, la válvula pre-SUH la asistencia primaria y las urgencias extrahospitalarias, y la válvula pos-SUH los servicios de apoyo al diagnóstico y los especialistas consultores. A partir de dicha concepción se clasifican los distintos tipos de saturación del SUH, se sistematizan sus causas y las diferentes colas de espera que generan, lo cual puede ayudar al rediseño del servicio y a prevenir su saturación y colapso.

https://doi.org/10.23938/assn.0002 1978 downloads

13.

Lista de espécies dos Scarabaeinae (Coleoptera, Scarabaeidae) do Estado de Mato Grosso do Sul, Brasil
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Vaz-de-Mello, Fernando Z.

; Bavutti, Leticia L. O.

; Flechtmann, Carlos A. H.

; Puker, Anderson

; Correa, César M. A.

Iheringia. Série Zoologia

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2017, Volume 107 elocation e2017120

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Apresenta-se nesse estudo uma lista atualizada das espécies de besouros rola-bostas reportadas para o estado de Mato Grosso do Sul, Brasil. Cento e dezoito espécies são reportadas, e associadas aos ecossistemas ou hábitats antropizados em que ocorrem no estado.

ABSTRACT In this study we present an updated checklist of species of dung beetles of the subfamily Scarabaeinae, occurrying in Mato Grosso do Sul state, Brazil. One hundred and eighteen species are reported and associated with ecosystems or antropized habitat within the state of Mato Grosso do Sul.

https://doi.org/10.1590/1678-4766e2017120 3228 downloads

14.

Experiencia con el uso del stent bioactivo cubierto con titanio-óxido nítrico comparado con stent liberador de zotarolimus: experiencia de una unidad médica de alta especialidad
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Garcia-Gutierrez, Juan C.

; Palacios-Rodríguez, Juan M.

; Cordova-Correa, Horacio G.

; Becerra-Laguna, Carlos A.

; López-López, Hugo A.

; Salinas Aragón, Miguel A

; García-Bonilla, Jorge

Archivos de cardiología de México

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Mar 2016, Volume 86 Nº 1 Páginas 18 - 25

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract: The use of coronary stents in coronary angioplasty has evolved dramatically in its design, type materials, polymers, and a variety of drugs, the use of coronary stents covered nitric oxide have shown satisfactory results in practice, however compared to the results reported drug-eluting stents, there is little information. Objectives: The aim of this study was to compare clinical outcomes of a stainless steel stent Bioactive nitric oxide coated titanium (BAS) and a drug-eluting stent zotarolimus (DES) in daily clinical practice. Methods: A retrospective, analytical, descriptive and comparative study aimed at evaluating the safety and efficacy of two devices with different characteristics in our population. The primary endpoints were: death, acute infarction (AMI), and re intervention injury Treated (RLT). Results: A total of 759 patients were included in the study which was performed angioplasty to a single vessel. Were divided into two arms 382 with DES and 377 patients with BAS, the one year follow up was carried in 95%. After this follow-up period, primary points (cardiovascular death, myocardial infarction, TLR and stent thrombosis) for arm DES vs BAS; 9.5% vs 8.5% P = NS but with shorter periods of dual antiplatelet therapy for arm BAS 6.9 ± 4.1 vs 11.1 ± 2.5 months DES P = .0001. The results were independent of the clinical syndrome of presentation. Conclusions: After one year of follow no statistically significant difference in major clinical events, there was a trend in favour of BAS vs SM with respect to revascularization of the target lesion without reaching statistical significance.

Resumen: Introducción: El uso de stents coronarios en la angioplastia coronaria ha evolucionado vertiginosamente en su diseño, tipo de materiales, polímeros y fármacos muy diversos. El uso de stents coronarios cubiertos de óxido nítrico han mostrado resultados satisfactorios en la práctica intervencionista; sin embargo, en comparación con los resultados reportados con stents liberadores de fármacos, se dispone de poca información. Objetivo: Comparar los resultados clínicos en la práctica clínica diaria de un stent bioactivo de acero inoxidable cubierto con titanio y óxido nítrico (BAS) y un stent liberador de fármaco (SLF) con zotarolimus. Métodos: Estudio retrospectivo, analítico, descriptivo y comparativo, cuyo objetivo fue evaluar la seguridad y la eficacia de dos dispositivos de diferentes características en nuestra población. Los puntos finales primarios a analizar fueron: muerte, infarto agudo de miocardio (IAM), y re intervención de la lesión tratada (RLT). Resultados: El estudio incluyó a 759 pacientes, a los cuales se les realizó angioplastia de un solo vaso. Estos se dividieron en dos brazos, 382 pacientes con SLF y 377 con BAS. Se realizó un seguimiento a un año en el 95%. Después de este periodo de seguimiento los puntos primarios (muerte cardiovascular, infarto de miocárdico, RLT y trombosis del stent) fueron similares para el brazo SLF vs. BAS; 9.5% vs. 8.5% p = NS pero con periodos más cortos de terapia dual anti plaquetaria para el brazo BAS 6.9 ± 4.1 vs. SLF 11.1 ± 2.5 meses p = 0001. Los resultados fueron independientes del síndrome clínico de presentación. Conclusiones: Después de un año de seguimiento no hubo diferencias estadísticamente significativas en cuanto a eventos clínicos mayores, y se presentó una tendencia a favor de BAS vs. SLF con respecto a la revascularización de la lesión tratada sin alcanzar significancia estadística.

https://doi.org/10.1016/j.acmx.2015.06.001 937 downloads

15.

Down- and Up-Conversion Photoluminescence of Carbon-Dots from Brewing Industry Waste: Application in Live Cell-Imaging Experiments
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Rodrigues, Carime V.

; Correa, José R.

; Aiube, Carlos M.

; Andrade, Lorena P.

; Galvão, Pedro M.

; Costa, Pâmela A.

; Campos, Ariadna L.

; Pereira, Anderson J.

; Ghesti, Grace F.

; Felix, Jorlandio F.

; Weber, Ingrid T.

; Neto, Brenno A.

; Rodrigues, Marcelo O.

Journal of the Brazilian Chemical Society

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Dez 2015, Volume 26 Nº 12 Páginas 2623 - 2628

Resumo: En | Texto: En | PDF: En

Simple synthetic procedures have been applied to obtain luminescent carbon quantum dots, also referred as C-dots, from an abundant carbon source, that is, from the brewing industry waste. The synthetic procedures have been conducted aiming to investigate the effects of the oxidation stage on the properties of the nanomaterial. C-dots down- and up-conversion properties, as well as their potential for cellular imaging experiments in live (and adhered) cells, are disclosed herein.

https://doi.org/10.5935/0103-5053.20150291 3549 downloads

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